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WebAug 24, 2024 · 该方法由Dixon和Mood首次提出,1985年Bruce又进行了改进,目前是OECD和EPA推荐的方法之一。其最大的特点是节省实验动物,同时,不但可以进行毒性表现的观察,还可以估算LD50及其可信限,适合于能引起动物快速死亡的药物。该方法分为限度试验和主试验。 WebA Bruceton analysis is one way of analyzing the sensitivity of explosives as described originally by Dixon and Mood in 1948. Also known as the "Up and Down Test" or "the staircase method", a Bruceton analysis relies upon two parameters: first stimulus and step size.A stimulus is provided to the sample, and the results noted. If a positive result is … shannon smith gwu
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