The human lysosome gene database
WebJul 11, 2011 · Experiments with chimeric proteins made up of sequences from RILP and RLP1 (RILPL1; 614092) revealed a 62-amino acid domain in RILP that was necessary to regulate lysosome morphology. The ability to regulate lysosomes correlated with the ability of the chimeric protein to interact with GTP-bound RAB7 or both GTP-bound RAB7 and … WebOpen table in a new tab. To investigate the cellular stress-induced transactivation of these non-TFEB–regulated genes, human lung carcinoma A549 and cervical cancer HeLa cells …
The human lysosome gene database
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WebGene provides a unified query environment for genes defined by sequence and/or in NCBI's Map Viewer. LOC118461668 lysosome-associated membrane glycoprotein 2-like [] Gene ID: 118461668, ... Other designations. lysosome-associated membrane glycoprotein 2-like ... WebHowever, the low methylation levels of the two methylated sites in the LAPTM5 gene was closely ... which was involved in negative regulation of B and T cell receptor on the cell surface via facilitating lysosome degradation. 12,13 ... et al. DiseaseMeth version 2.0: a major expansion and update of the human disease methylation database. ...
WebJun 25, 2009 · Fig. 1 A regulatory gene network controlling the expression of lysosomal genes. (A) Genomic distribution of CLEAR elements (red dots) at human gene …
WebJun 7, 2024 · Lysosomes are degradation centers and signaling hubs in cells and play important roles in cellular homeostasis, development, and aging. Changes in lysosome function are essential to support cellular adaptation to multiple signals and stimuli. Therefore, lysosome biogenesis and activity are regulated … Lysosome biogenesis: … WebApr 15, 2024 · The GO analysis is a commonly used approach providing functional studies of large-scale genomic or transcriptomic data. 24 Kyoto Encyclopedia of Genes and Genomes (KEGG) database collects the pathway-related information about how molecules are networked. 25 In the present study, the GO functional analysis comprising three ontology …
WebProvided are a constitutive promoter CAR-Mut, an expression construct comprising the promoter and a GAA coding nucleotide sequence functionally linked thereto, a recombinant vector, and a host cell. Also provided are a composition and method for delivering a GAA coding polynucleotide to a mammalian cell or individual using the recombinant vector, …
WebDec 10, 2024 · Lysosomes have recently been recognized as ‘acidic Ca 2+ stores’, and lumenal Ca 2+ is central to diverse functions 3. Lysosome function is particularly important in neurons given the... ray wagner mattelWebFeb 1, 2007 · It is reported that the gene encoding the Drosophila ortholog of the HPS5 subunit of BLOC‐2 is identical to the granule group gene pink (p), which was first studied in 1910 but had not been identified at the molecular level. Lysosome‐related organelles comprise a group of specialized intracellular compartments that include melanosomes … simply smarter shoppingWebNov 2, 2024 · We identified 604 genes and created main categories: MTOR and upstream pathways, autophagy core, autophagy transcription factors, mitophagy, docking and … ray wagstaff obituaryWebLysosome-associated membrane protein 2 ( LAMP2 ), also known as CD107b ( C luster of D ifferentiation 107b) and Mac-3, is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins . The protein encoded by this gene is a member of a family of membrane glycoproteins. ray wagner and associatesWebJun 25, 2009 · We found that most lysosomal genes exhibit coordinated transcriptional behavior and are regulated by the transcription factor EB (TFEB). Under aberrant lysosomal storage conditions, TFEB translocated from the cytoplasm to the nucleus, resulting in the activation of its target genes. ray wade cateringWebA screen of the SWISS-PROT database [15] for proteins that harbour PTS1 signals produced a set of lyosozymes, well characterized secreted enzymes that are not usually found in peroxisomes. simply smarter marketingWebThus, there is a continuing interest in understanding the cellular functions of the lysosome and an emerging approach to this is the identification of its constituent proteins by proteomic analyses. To date, the mammalian lysosome has been shown to contain approximately 60 soluble luminal proteins and approximately 25 transmembrane proteins. ray wagner missouri