Taxol metabolism in rat hepatocytes
WebAbstract. Primary cultured adult rat hepatocytes were used to study regulation of thyroid hormone deiodination. Control studies showed that these cells survived for at leas 4 d, … WebNov 28, 2024 · Three decades of hepatocyte transplantation have confirmed such a cell-based approach as an adjunct or alternative treatment to solid organ transplantation. …
Taxol metabolism in rat hepatocytes
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WebDec 31, 1994 · The antitumor drug taxol was metabolized to two major metabolites (RM1 and RM2) in adult male and female rat liver microsomes. The male rats produced RM1 2.6 … WebJul 1, 2004 · We investigated cytochrome P450 (P450)-catalyzed metabolism of the important cancer drugs paclitaxel and docetaxel in rat, pig, minipig, and human liver …
Web× Close. The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such … WebThis study with a placebo-controlled experimental design intends to investigate the effect of Royal Jelly (RJ) on the testosterone levels in sedentary men at a dose of 1000 mg/day. …
WebVarious cryopreservation techniques have been investigated to extend the storage of isolated hepatocytes; however, most have a reduced viability after rewarming due to ice crystal formation. Subzero nonfreezing conditions could theoretically reduce organ metabolism without damage due to ice crystal formation. In the present work we … WebNov 2, 1993 · Metabolism of the anticancer drug taxol was investigated in freshly isolated rat hepatocytes. Two main metabolites were separated by reversed-phase HPLC and …
WebTaxol is a natural product, isolated from Taxus brevifolia, with increasing clinical applications because of its potent antitumor activity. Although it is mainly metabolized in …
WebN-Acetyl-L-cysteine (NAC) and L-2-oxothiazolidine-4-carboxylate (OTC) are converted enzymatically to cysteine and have been used to stimulate hepatic glutathione synthesis. Using hepatocytes isolated from male Sprague-Dawley rats and 35S-labeled substrates, the uptake and metabolism of these cysteine precursors was measured and compared with … how to clean a black felt cowboy hatWebIn order to clarify hepato-protective actions of estrogen, we examined the progress of carbon tetrachloride (CCl4)-induced acute liver injury (ALI) in… how to clean a bird cageWebHepatic mitochondrial functions related to fatty acid metabolism, including the respiratory control ratio, fatty acid oxidative capacity and carnitine palmitoyltransferase I activity, … how to clean a black chalkboardWebJan 1, 1997 · In this study, the response of isolated rat hepatocytes to taxol was evaluated by correlating the changes observed in global indexes such as viability and heat … how to clean a biopsy woundWebFeb 8, 2024 · The rat is a widely-used model for human biology, but we must be aware of metabolic differences. Here, the authors reconstruct the genome-scale metabolic network … how to clean a belly buttonWebDownload and Read Books in PDF "Comparative Sensitivity Of Chicken And Rat Adipocytes And Hepatocytes To Isologous And Heterologous Pancreatic Hormones" book is now available, Get ... thyroid hormones, and corticosteroids in the control of fatness in birds. Part V covers studies involving amino acid metabolism and its relation to leanness ... how to clean a black glass dry erase boardWebThe biliary excretion of Taxol has been studied in rats and in a human patient receiving Taxol in a phase I trial, and the chemical structures of four of the rat metabolites and … how to clean a bkr bottle