Proarrhythmic properties
Webb24 maj 2024 · In addition, numerous studies reported proarrhythmic properties of cannabinoids including ventricular arrhythmias and even sudden cardiac death (Courts et al. 2016; Ozturk et al. 2024; Manolis et al. 2024 ). However, the mechanism of these arrhythmias remains unclear (Ozturk et al. 2024 ). Webb25 nov. 2016 · Ranolazine was also synthesized for the development of antianginal properties that stem from a partial inhibition of fatty acid oxidation; it too has been …
Proarrhythmic properties
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WebbRanolazine was also synthesized for the development of antianginal properties that stem from a partial inhibition of fatty acid oxidation; it too has been found to have …
WebbProarrhythmia is predominantly associated with slow use-dependent conduction (e.g., incessant ventricular tachycardia) during treatment with class IC drugs or a reverse use-dependent effect on refractoriness (e.g., torsade de pointes during treatment with class IA drugs or drugs with pure class III action). 8,10–14 Proarrhythmia is described as … Webb1 apr. 2006 · Each compound reduced the heart rate dose-dependently from 600 to 200 bpm with ED 50 values of 1.2, 4.7, and 1.8 mg/kg for cilobradine, ivabradine, and zatebradine, respectively. β-Adrenergic stimulation or forced physical activity only partly reversed this bradycardia.
WebbWe evaluated proarrhythmic risk of intravenous oseltamivir with chronic atrioventricular block canine model (n = 4) and action-potential assay on guinea-pig right ventricle (n = 5). Oseltamivir in doses of 3-30 mg/kg, i.v. did not induce torsade de Webb3 juni 2011 · Proarrhythmic properties of propofol Some studies have demonstrated that propofol has the potential to block the conduction system of the heart and thereby …
Webb24 dec. 2024 · Notably, none of the studied compounds at the highest tested dose, i.e., 5 mg/kg, affected the QT interval and exposed the proarrhythmic potential. Therefore, if arylpiperazine alkyl derivatives showed no torsadogenic potential at the higher doses, we may assume that they do not possess proarrhythmic properties at lower doses.
WebbElsholtzia ciliata essential oil (E. ciliata) has been developed in Lithuania and internationally patented as exerting antiarrhythmic properties. Here we demonstrate the pharmacological effects of this herbal preparation on cardiac electrical activity. We used cardiac surface ECG and a combination of microelectrode and optical mapping techniques to track the … bioactive nutritional homeopathicWebbAims: Whether therapeutic hypothermia (TH) is proarrhythmic in preexisting failing hearts with acute ischemia–reperfusion (IR) injury is unknown. Additionally, the effectiveness of rotigaptide on... bioactive nutritional companyWebb22 okt. 2024 · In conclusion, CQ- and AZM-induced proarrhythmia is promoted by conditions with reduced repolarization reserve. Sympathetic stimulation limits drug … daewon semiconductor packaging industrial coWebb22 apr. 2013 · A quantitative description of emergent proarrhythmic properties of restitution, conduction velocity, and alternans regimes as a function of temperature is … daewoo 12l rotisserie air fryer manualWebb21 juli 2015 · Drug-induced proarrhythmia is defined as the occurrence of potentially lethal arrhythmias as a result of previous or concomitant pharmacological treatment. Various cardiovascular or... dae won kim moffittProarrhythmia is a new or more frequent occurrence of pre-existing arrhythmias, paradoxically precipitated by antiarrhythmic therapy, which means it is a side effect associated with the administration of some existing antiarrhythmic drugs, as well as drugs for other indications. In other words, it is a tendency of antiarrhythmic drugs to facilitate emergence of new arrhythmias. bioactive nutritional productsWebb17 feb. 2024 · The mechanisms underlying arrhythmia induced by the clinical use of azithromycin are poorly understood. We aimed to investigate the proarrhythmic effects of azithromycin using electrocardiogram (ECG) and ion channel models. In vivo and in vitro guinea pig ECG and current and voltage clamp recordings were carried out. Azithromycin … daewonsys.com