Web7 feb. 2013 · GSH, as a single agent, is found to affect DNA damage and repair, redox regulation and multiple cell signaling pathways. Thus, seemingly, GSH does not only act … Web11 apr. 2024 · The second fraction of papers in this Special Issue focuses on the role of DNA replication, DNA repair, and DDR in maintaining the integrity of telomeres, the dysregulation of which has a great impact on a variety of human diseases, including aging and cancer [].Human telomeres are unique genomic sequences found at the end of each …
Reduced Glutathione: A Radioprotector or a Modulator of DNA …
Web1 apr. 1996 · In a randomized double-blind trial of alpha-tocopherol (vitamin E), we investigated the effects of alpha-tocopherol supplementation on lipid- and water-soluble antioxidants in plasma and DNA repair activities in peripheral mononuclear leukocytes. Web27 mar. 2024 · The Rad6-Rad18 ubiquitin-conjugating enzyme complex of Saccharomyces cerevisiae promotes replication through DNA lesions via three separate pathways that include translesion synthesis (TLS) by DNA polymerases ζ (Polζ) and Polη and postreplicational repair mediated by the Mms2-Ubc13 ubiquitin-conjugating enzyme and … mappa probation service
Sulfasalazine, an inhibitor of the cystine-glutamate antiporter ...
WebDNA damage induces an increase in nuclear levels ( PubMed: 20154705 ). Together with FIGNL1, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) or camptothecin (CPT) treatment ( PubMed: 23754376 ). Accumulated at sites of DNA damage in a SPIDR-dependent manner ( PubMed: 23509288 ). Webdiet-induced, organ-specific colonic lysine homo-cysteinylation (K-Hcy) increase might promote CRC onset by impeding DNA damage repair. HF chow induced elevated methionyl-tRNA synthetase (MARS) expression and K-Hcy levels and DNA dam-age accumulation in the mouse and rat colon, result-ing in a phenotype identical to that of … Web27 dec. 2010 · Histone methylation mediates localization of 53BP1 to a DNA double-strand break (DSB) during homologous recombination repair, but a role in DSB repair by nonhomologous end-joining (NHEJ) has not been defined. By screening for histone methylation after DSB induction by ionizing radiation we found that generation of … mappa primo capitolo promessi sposi