L-selectin, also known as CD62L, is a cell adhesion molecule found on the cell surface of leukocytes, and the blastocyst. It is coded for in the human by the SELL gene. L-selectin belongs to the selectin family of proteins, which recognize sialylated carbohydrate groups containing a Sialyl LewisX (sLeX) … Meer weergeven The nature of the interactions between L-selectin and ligand depends on many circumstances, primarily the location of anatomically defined sites in the high vessel venules (perivascular, extravascular … Meer weergeven L-selectin is expressed constitutively on most circulating leukocytes. Over time, these molecules are released through the process of ectodomain shedding and are replaced by newly synthesized L-selectin proteins. Ectodomain shedding is largely accomplished … Meer weergeven Human immunodeficiency virus (HIV) L-selectin expressed on CD4 T lymphocytes has been implicated in mediating … Meer weergeven • L-Selectin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • Immunology at MCG 1/physresp • Overview of all the structural information available in the Meer weergeven Lymphocytes L-selectin acts as a "homing receptor" for lymphocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present … Meer weergeven • Ryan US, Worthington RE (February 1992). "Cell-cell contact mechanisms". Current Opinion in Immunology. 4 (1): 33–37. doi:10.1016/0952-7915(92)90120-4. PMID 1375831. • Nicholson IC (2003). "CD62L (L-selectin)". Journal of Biological Regulators … Meer weergeven Web1 jan. 2001 · — Selectins are a family of three cell adhesion molecules (L-, E-, and P-selectin) specialized in capturing leukocytes from the bloodstream to the blood vessel wall. This initial cell contact is followed by the selectin-mediated rolling of leukocytes on the endothelial cell surface.
Cells Free Full-Text Selectin-Mediated Signaling&mdash ... - MDPI
Web15 okt. 1993 · Abstract. The adhesive interactions between leukocyte L-selectin and the endothelium are involved in the migration of lymphocytes through peripheral lymph nodes and of neutrophils to sites of inflammation. A recombinant L-selectin stains high endothelial venules (HEVs) in lymph nodes and recognizes sulfated carbohydrates found on two ... Webmediated to a great extent by binding of platelet P-selectin to P-selectin glycoprotein ligand-1 (PSGL-1) expressed on leuko-cytes.5 This function of supporting leukocyte capture and rolling by platelets is particularly important in the setting of arterial injury, in which endothelial denudation exposes the subendothe- newforestplayers.com
Early Targeting of L-Selectin on Leukocytes Promotes Recovery
WebSelectins are a diverse group of calcium-dependent, type I transmembrane molecules that bind to sialylated, fucosylated carbohydrates, function in vascular adhesion, and play a … WebIn mouse models of solid tumors, platelets have been shown to promote blood-borne metastasis 6-8 and safeguard the tumor vasculature. 9 Moreover, a correlation between increased platelet counts and shorter patient survival times has been described for several solid tumors. 7, 10-12 Both pharmacological inhibition of platelet function and transient … Web1 dag geleden · Gut Microbiome: Eubiosis and Dysbiosis. The number of bacterial cells living in and on our body roughly equals the number of human cells in the body, which is around 30 trillion (3x10 13). 12,13 Such a large number of metabolically active cells has a major influence on body functions and health. In normal conditions, the gut microbiota … new forest photos