Ddc 3 5-diethoxycarbonyl-1 4-dihydrocollidine
WebOct 25, 2024 · We recently described a murine model of CLD-induced sarcopenia by intake of hepatotoxin 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), which presents an increase in plasma bile acids (BA). BA induced skeletal muscle atrophy through a mechanism dependent on the Takeda G protein-coupled receptor 5 (TGR5) receptor. Web3,5-diethoxycarbonyl-1,4-dihydrocollidine; 4weeks; 4wk; 5-bromo-2-deoxyuridine; ALT; Apoptosis resistance; BM; BMT; BrdU; Casp; Casp8 knockout allele; Casp8 knockout mice; Casp8(loxP/loxP); Casp8(ΔMx); Casp8(Δhepa); Caspase; Caspase-8; DDC; Hepatic immune cells; LPC; Mx1; NPCs; PCR; Progenitor cells; RT; SD; Secondary sclerosing …
Ddc 3 5-diethoxycarbonyl-1 4-dihydrocollidine
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WebOct 21, 2024 · Hepatic fibrosis is characterized by excessive extracellular matrix deposition and ductular reactions, manifested as the expansion of hepatic progenitor cells (HPCs). We previously reported that the Y-box binding protein 1 (YB-1) in … WebChronic feeding of 3,5-diethoxycarbonyl-1,4-dihydrocollidine, named DDC, has been proposed as an in vivo model for cholestatic disease due to the formation of intraductal porphyrin plugs.
WebNov 26, 2024 · Otherwise, 2-allyl-2-isopropylacetamide (AIA) and 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) induce a series of enzymatic disruptions which are considered to resemble variegate porphyria . Fasting induces ALAS1 expression via the peroxisome proliferator-activated receptor γ coactivator 1 α (PGC-1 α ) [ 29 ]. WebMethods: C57BL/6 mice were fed a choline-deficient, ethionine-supplemented (CDE) diet or a diet containing 0.1% 3,5-diethoxycarbonyl-1, 4-dihydrocollidine (DDC) for up to 4 weeks to induce chronic liver injury. We used quantitative liver intravital microscopy (qLIM) for real-time assessment of bile transport and BBlB integrity in the intact ...
http://www.zhbybio.com/newsinfoen/4612.html?page=5 WebExposure of mice to a diet containing 3,5-diethoxycarbonyl-1, 4-dihydrocollidine (DDC) induces porphyrin accumulation, cholestasis, immune response, and hepatobiliary …
Web3,5-Diethoxycarbonyl-1,4-dihydrocollidine (DDC) is a liver toxic agent, and DDC-enriched diet is used to induce chronic hepatitis (CH) in mice. References Atypical ductular …
Web1. Dissolve DPC powder in chloroform to up to 50 mg/mL. 2. Measure out the appropriate amount of DPC in chloroform for a desired final volume and concentration, and dry … filis food truckWebIn vivo, cholestatic mice induced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) were treated with apigenin. Apigenin potently blocked DDC-induced gallbladder atrophy and associated liver injury, fibrosis and collagen accumulation. filisian instituteWebAug 11, 2024 · The 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet model is a widely used animal model for cholestatic liver diseases [14,15]. DDC is a porphyrinogenic agent … filis freiburgWebPro-inflammatory factors including TNF-α (C), IL-6 (D) in serum on ELISA. S1PR2, sphingosine 1-phosphate receptor 2; DDC, 3,5-diethoxycarbonyl-1,4-dihydrocollidine; … grounded 123moviesWebOct 1, 1974 · 3,5-Diethoxycarbonyl-1,4-dihydrocollidine (DDC) is a porphyrinogenic agent and is a powerful inducer of δ-aminolaevulinate synthetase, the first and rate-limiting enzyme of the haem-biosynthetic pathway, in mouse liver. grounded 13WebSep 12, 2016 · The 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet induces a cholangiopathy and is well validated to study the mechanisms of chronic cholangiopathies. grounded 1.1 update release dateWebMar 5, 2024 · Cholestasis was induced in both models by bile duct ligation (BDL) or 3.5-diethoxycarbonyl-1.4-dihydrocollidine (DDC) feeding. ... aspartate aminotransferase; BDL, bile duct ligation; BSEP; CDX2, caudal type homeobox 2; Cholestasis; DDC, 3.5-diethoxycarbonyl-1.4-dihydrocollidine; FGF, fibroblast growth factor; FXR; FXR, … filisia interfaces ltd