2024 Cholesterol homeostasis gsea

Cholesterol homeostasis gsea

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August undefined, 2024

WebNov 5, 2024 · To investigate the roles of cholesterol homeostasis in terminal erythropoiesis, we used a well-established ex vivo mouse fetal liver cell culture system, in which TER119-negative erythroblasts isolated from E14.5 fetal liver (FLCs) were differentiated into enucleated reticulocytes in vitro. ... GSEA of the transcriptome … WebApr 6, 2024 · In this work, to better understand how Tregs develop and exert suppressive functions in the NPC microenvironment from an integrated multi-omic perspective, we show that CD70+ NPC cells can enhance...

Mechanisms and regulation of cholesterol homeostasis - PubMed

WebNov 28, 2024 · Moreover, GSEA showed that 24OHC was associated with positive regulation of cholesterol efflux, but negatively associated with gene signatures linked to cholesterol homeostasis, SREBP targets and stem cell proliferation (Fig 5D). A volcano plot of the RNA-seq results revealed significant changes in several target genes of two … WebJan 4, 2024 · Our observations show that modulation of cholesterol homeostasis is a major effect of necrotic cell debris and STING and suggest that combining STING agonists with statins may help control tumor growth. ... Gene Set Enrichment Analysis (GSEA) ... how to describe range in music

GOBP_LIPID_HOMEOSTASIS - GSEA MSigDB

WebCholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed cholesterol balance underlies not only cardiovascular disease but also an increasing … WebFeb 10, 2024 · b Enrichment plot of the cholesterol homeostasis pathway after ENSA knockdown in MDA-MB-231 cells. ... GSEA gene set enrichment analysis, NES normalized enrichment score. WebNov 10, 2024 · Cholesterol homeostasis is essential for health. Cholesterol serves as a precursor of various steroid hormones, bile acids, and vitamin D. Besides, cholesterol is an essential component of cell membrane and provides lipid for cell proliferation. how to describe rage in writing

Therapeutic implications of altered cholesterol homeostasis mediated by ...

Nasopharyngeal carcinoma cells promote regulatory T cell …

WebThe hallmark cholesterol homeostasis gene set includes 74 genes; 38 genes were part of the leading edge with an NES of 2.1 (Figure 5C and Figure S1C). ... GSEA of cholesterol homeostasis pathways show upregulation of genes … Webv. t. e. In biology, homeostasis ( British also homoeostasis) (/hɒmɪə (ʊ)ˈsteɪsɪs/) is the state of steady internal, physical, and chemical conditions maintained by living systems. [1] This is the condition of optimal … the most sustainable dietWebCholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed cholesterol balance underlies not only cardiovascular disease but also an increasing number of other diseases such as neurodegenerative diseases and cancers. The cellular cholesterol level reflects the dynamic bal … how to describe raynauds

"WebGene Set Enrichment Analysis (GSEA) is a computational method that determines whether an a priori defined set of genes shows statistically. significant, concordant differences between two biological states. (e.g. phenotypes). Download the GSEA software and additional resources to analyze, annotate and interpret enrichment results. " - Cholesterol homeostasis gsea

Cholesterol homeostasis gsea

Frontiers Cholesterol Metabolism: A Double-Edged Sword in ...

WebOct 11, 2024 · We demonstrate that RORγ functions as an essential activator of the entire cholesterol-biosynthesis program, dominating SREBP2 via its binding to cholesterol-biosynthesis genes and its facilitation of the recruitment of SREBP2. WebApr 9, 2012 · Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipid-loaded macrophages in the arterial wall. We demonstrate that macrophage lipid body formation can be...

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WebNov 1, 2024 · Conclusion: We constructed and validated a cholesterol homeostasis-related gene signature to predict the prognosis of EC, which correlated to immune infiltration and expected to help the diagnosis ... WebMar 17, 2024 · The analysis with GO, KEGG, and GSEA pathways was enriched in cholesterol metabolism, regulation of lipolysis in adipocytes, and amino acid metabolism. ... Interestingly, studies have shown that the dysregulation of intracellular calcium homeostasis in cardiac myocytes is an important factor in exacerbating the …

WebApr 6, 2024 · Pathway analysis revealed that fatty acid metabolism, cholesterol homeostasis, and mitochondrial functions were top enriched signatures in CD70 … WebDec 17, 2024 · Cholesterol homeostasis at systemic levels requires collaboration between various tissues, which ensures a balance between cholesterol absorption (in the …

Web1. Introduction. Cholesterol is a unique lipid that plays an essential role in membrane biogenesis. In mammals, cholesterol is principally obtained from diet and de novo biosynthesis by the liver and is distributed throughout the body via low-density lipoprotein (LDL) and high-density lipoprotein [1].Nowadays, due to overnutrition and sedentary … WebJul 15, 2024 · GOBP_LIPID_HOMEOSTASIS: Systematic name: M12045: Brief description: Any process involved in the maintenance of an internal steady state of lipid within an organism or cell. [GOC:BHF, GOC:rl] Full description or abstract : Collection: C5: Ontology GO: Gene Ontology GO:BP: GO Biological Process: Source publication : Exact source: …

WebApr 10, 2024 · Since Srebp1 is a master transcription factor for cholesterol synthesis, this increase was potentially due to a compensatory effect on cholesterol production. For lipid degradation pathways, strong decreases in β-oxidation genes were observed in Irs1 and Bcl6 KO livers ( Figure 6 F, upper panel), likely because these livers had the least ...

WebMay 17, 2024 · Background Disturbance of cholesterol homeostasis is considered as one of the manifestations of cancer. Cholesterol plays an essential role in the pleiotropic … how to describe puppy dog eyesWebApr 12, 2024 · We explored the effect of thrombin on human aortic smooth muscle cells (HASMCs) and further analyzed its role in the pathogenesis of atherosclerosis (AS). Thrombin-induced differentially expressed genes (DEGs) in HASMCs were identified by analyzing expression profiles from the GEO. Subsequently, enrichment analysis, GSEA, … the most syracuseWebPancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with a dismal prognosis. PDAC have extensively reprogrammed metabolic characteristics influenced by interactions with normal cells, the effects of the tumor microenvironment and oncogene-mediated cell-autonomous pathways. In this study, we found that among all cancer hallmarks, … how to describe rate of speechWeb胆固醇（cholesterol ）是哺乳动物体内含量最丰富的甾醇类分子，是细胞膜的基本组分之一，能与邻近脂类分子作用调节膜的刚性、流动性和渗透性，或与跨膜蛋白结合维持或改变后者的构象。胆固醇也是氧化甾醇和甾 … how to describe queen elizabeth iiWebJan 3, 2024 · INTRODUCTION. Liver is the primary organ responsible for the maintenance of lipid homeostasis. When excessive lipid accumulation overwhelms the capacity of the liver to store, secrete, and oxidize, NAFLD occurs. 1 NAFLD represents a spectrum of hepatic diseases and is associated with the development of metabolic disorders, such as … how to describe reason for leaving jobWeba, GSEA of differentially expressed genes in human OA for the cholesterol homeostasis pathway (left, top) and the mTOR signaling pathway (left, bottom). False discovery rate (q-value) and ... how to describe red eyes in writingWebCholesterol metabolism is altered to enhance the senescence-associated secretory phenotype a, GSEA of differentially expressed genes with a focus on metabolic pathways during DNA damage-induced ... how to describe red hair